"Mama" follows three different families all dealing with different issues affecting their mothers.

Dong-Sook (Uhm Jung-Hwa) is a single mother who works as a saleswoman for yogurt drinks and also works cleans apartments to make ends meet. Her world revolves around her son Won-Jae (Lee Hyung-Suk), who is afflicted with a disease that prevents him from walking. One day, Dong-Sook is diagnosed with cancer and her world comes crashing down ...

Eun-Sung (Ryu Hyun-Kyung) has always lived under the shadows of her famous opera singer mother Hee-Kyung (Jeon Su-Kyeong). Even as a married mother, Eun-Sung still at times feels like an assistant to her mother rather than a daughter. Eun-Sung's dreamed as a child of becoming a pop-singer, but her uppity mother would have none of that. As an adult can Eun-Sung achieve her dream?